Real Madrid travel to England tonight with their hopes of claiming La Decima hanging in the balance; after a relatively disappointing first-leg draw at the Santiago Bernabeu, Los Blancos need a high scoring draw or better yet, a win, to secure their place in the quarter-finals. However, they face tough opposition in the form of Sir Alex Ferguson's table-topping Manchester United. Despite the omission of England international Wayne Rooney, SAF has selected a strong XI, featuring Ryan Giggs who is making his 1000th senior appearance.
Elsewhere, Borussia Dortmund welcome Ukrainian champions Shakhtar Donetsk following a 2-2 first-leg draw at the Donbass Arena. Will Jurgen Klopp's Bundesliga winning side be able to book their place in the quarter-finals or will Shakhtar reach the final eight for the second time in the last three seasons?
Man Utd XI: De Gea, Rafael, Ferdinand, Vidic, Evra, Carrick, Giggs, Cleverley, Nani, Welbeck, Van Persie
Real Madrid XI: Lopez, Arbeloa, Varane, Ramos, Coentrao, Alonso, Khedira, Di Maria, Ozil, Ronaldo, Higuain
Borussia XI: Weidenfeller; Piszczek, Subotić, Felipe Santana, Schmelzer; Gündoğan, Bender; Błaszczykowski, Götze, Reus; Lewandowski
Shakhtar XI: Pyatov, Kucher, Rat, Srna, Rakitskiy, Hubschman, Fernandinho, Mkhitaryan, Taison, Teixeira, Adriano