Also in the 20-man list are Denis Suarez, Paco Alcacer, Yerry Mina and Andre Gomes as well as a host of youngsters.
Here’s a look at the full squad list.
Wednesday’s game is chance for some of Barca’s fringe players and young stars to impress, and it will be interesting to see how strong a team Ernesto Valverde picks.
Who do you think should feature against Espanyol? Let us know your thoughts and lineups in the comments below!