Barça were knocked out by AS Roma last season, with critics suggesting the Catalans may have underestimated their opponent.
Lyon are considered heavy underdogs but they have already sparked an upset this term in the Champions League, beating Manchester City, one of the competition favorites, 2-1 in the group stage.
“It doesn’t matter how well you’ve done during the competition or in previous seasons,” the World Cup, European Championship , and Champions League winner said.
“We have been warned by what’s happened other seasons, and we are clear that we have to be ambitious.
“Lyon are a dangerous rival. We expect them to be at their best. They have gone through a great group stage, without losing, with players with great attacking potential.
“In the Champions League, we have played really good games and we have to keep that streak going. We have been warned, we must do our best.”