Quique Setien doesn’t have many injuries to contend with but is expected to make changes again and will definitely be without Samuel Umtiti due to suspension.
Let’s have a look at how they might line up:
Jordi Alba will return to the starting XI after serving a one-match ban and should replace Junior Firpo at left-back, while we could see Nelson Semedo take over from Sergi Roberto on the right.
Gerard Pique should be fit to start despite needing treatment after a nasty knock against Leganes and will partner Clement Lenglet in central defence.
There is where things should get interesting with several players all pushing for a start in the Barca midfield.
Arturo Vidal looks set to return and will need to be careful as he’s one yellow card away from a ban, while Frenkie de Jong could also return to the starting XI.
Sergio Busquets is another player who looks likely to get the nod, although Arthur and Ivan Rakitic are also both available. Riqui Puig is also an option after a bright cameo on Tuesday.
Setien also has plenty of decisions to make in attack. Fit-again Luis Suarez is yet to start after recovering from knee surgery, was he being saved for this one?
Ansu Fati’s goal against Leganes makes him a serious contender for a starting spot, while Martin Braithwaite will be fresh as he was not used at all in midweek.
Lionel Messi looks set to lead the team out again, but there are questions marks over Antoine Griezmann after another underwhelming performance against Leganes.
Possible XI: Ter Stegen; Semedo, Pique, Lenglet, Alba; Vidal, Busquets, De Jong; Messi, Suarez, Braithwaite.
How do you think Barcelona will line up against Sevilla? Let us know your thoughts, predictions and line-ups in the comments below!