Sergi Roberto picked up a fresh injury on Wednesday which forced him out of Barcelona’s Copa del Rey quarter-final clash with Granada.
The versatile star was making his first start since November, after returning from two months out, but had to come off early in the second half.
Barcelona confirmed it’s another thigh injury, but it’s not clear yet how serious the problem is or how long the 28-year-old might be out for.
Sergino Dest, who has also only just returned to full fitness, came on and made his first appearance since the Super Cup final.
Ronald Koeman also has Oscar Mingueza available to play on the right side of defense if it turns out that Roberto is set for another spell on the sidelines.
Barca return to action on Sunday at Real Betis in La Liga.