Barca go into the game with a big lead and a win would see them go into the winter break with a 14 point lead over their rivals.
Iniesta has explained just how Barca need to play on Saturday, if they are to take all three points back to Camp Nou.
“To win at the Bernabeu we have to be the protagonist, to dominate the ball and the game as much as we can and above all to be effective when we have chances,” he said.
“Madrid generate many opportunities at home and we have to minimise their chances.”
Source | Mundo Deportivo
Iniesta has also rejected claims that a Barca win would effectively rule Madrid out of the title race, as he feels there are too many games left.
“It would be another step towards our goal of winning La Liga. To speak of a blow to Madrid would be an error because there are many points left,” he added.
“Any slip can cut the gap. You also have to see what the teams in second and third do, in this case Atlético and Valencia but the idea is to keep moving forward.”
Of course Real Madrid blew Barca away in the Spanish Super Cup in August, winning 3-1 at Camp Nou and 2-0 at the Bernabeu.
However, much has changed since then, los Blancos have not had the dominant season most expected, while Barca are top and yet to lose.