The Blaugrana go into the game top of the table, albeit having played a game more, following their El Clasico success with the title race now very much back on.
Up next are La Liga’s bottom side, who have managed just three wins all season, but Enrique has warned his team against complacency.
"We have to be prepared and make sure we don't slip up," he told his pre-match press conference.
"Matches at the end of the season can be more dangerous, especially against teams at the bottom, fighting, as Osasuna are.
"We have had problems against teams in bottom half this season. We have to focus on the end of season and keep picking up points. There are no easy opponents, not least Osasuna."
Enrique also says Barcelona should not be considered title favourites and feels both his side and Real Madrid could drop points before the end of the campaign.
"No, I don't have the feeling we're favourites now," he added. "Madrid have a game more than us, so can move back ahead of us.
"Both teams will have a difficult time between now and end of the season. There will be surprises, for sure, and results people don't expect."