Ernesto Valverde’s side are massive favourites to win, but they will know they were beaten 1-0 on their last visit to the ground over four years ago.
Real Valladolid opened up their campaign with a 0-0 draw against Girona. Since then they have brought in some new players with Enes Ünal, Leo Suarez and Duje Cop all arriving on loan.
Let’s have a look at how Barcelona might line up for the match:
It’s unlikely there will be too many changes in defence from Barcelona’s opening game against Alaves.
The only two real possibilities are at right-back where Sergi Roberto may come in for Nelson Semedo, and at centre-back where Clement Lenglet is an option.
There’s likely to be changes in midfield from the opening game where Roberto started in midfield but it didn’t really work out.
Philippe Coutinho is likely to return after coming off the bench last weekend and scoring Barcelona’s second goal.
Sergio Busquets and Ivan Rakitic also look likely to keep their places unless Valverde fancies giving either Arturo Vidal or Arthur a first La Liga start.
It’s fair to say that Luis Suarez has not enjoyed the best start to the new season. However, this looks a decent opportunity for him to finally get off the mark.
In stark contrast Lionel Messi is off to a flyer. He bagged two goals against Alaves, hit the woodwork twice and was easily the man of the match.
Ousmane Dembele could complete the attack after starting against Alaves. The Frenchman lacked a bit of composure in the final third last time out but seems to have Valverde’s trust for now.
Possible XI: Ter Stegen; Roberto, Pique, Umtiti, Alba: Rakitic, Busquets, Coutinho; Messi, Suarez, Dembele.
How do you think Barcelona should line up on Saturday? Let us know your thoughts, line-ups and predictions in the comments below!