Ernesto Valverde’s side will be missing some key players due to injury and suspension, so let’s have a look at who may feature against Julen Lopetegui’s men.
Clement Lenglet is suspended for this clash, while Samuel Umtiti, Junior Firpo and Jordi Alba are all injured and not expected back in time for the game.
All of which means the defence virtually picks itself. Sergi Roberto and Nelson Semedo will continue on the flanks, while Gerard Pique and Jean-Clair Todibo will start in central defence.
Ernesto Valverde has decisions to make over his midfield where Arturo Vidal will be hoping he has done enough to play his way into the starting XI
The Chilean played a key role for the club after replacing Sergio Busquets in midweek in the Champions League but is yet to start for Barca this season.
Busquets, Frenkie de Jong and Arthur have emerged as Valverde’s favoured midfield trio, while Ivan Rakitic and Carles Alena have barely had a look-in.
Barcelona’s injury problems in attack are easing with Lionel Messi and Ousmane Dembele back to full fitness, although Ansu Fati remains on the sidelines.
Messi and Luis Suarez look the players most likely to be in the starting XI, with Dembele vying with Antoine Griezmann for the final spot in the attack.
Possible XI: Ter Stegen; Roberto, Pique, Todibo, Semedo; De Jong, Busquets, Arthur; Messi, Suarez, Griezmann.
How do you think Barcelona will line up against Sevilla? Let us know your thoughts, predictions and line-ups in the comments below!