As such there is likely to be some rotation from Ernesto Valverde, so let’s have a look at who might feature.
Barcelona could make changes in defence, and it’s even possible we might see Samuel Umtiti back in action after a long lay-off with knee trouble.
The Frenchman is fit again and is an option to partner Gerard Pique in central defence.
Clement Lenglet could also continue, while Thomas Vermaelen is out injured again and Jeison Murillo seems to have been forgotten about altogether.
At right-back it seems that Nelson Semedo is now deservedly first choice, but it could be that he gets a breather and is replaced by Sergi Roberto.
Jordi Alba should continue at left-back with Marc-Andre ter Stegen taking his usual place between the sticks.
Into midfield where Sergi Roberto was a surprise inclusion against Lyon alongside Ivan Rakitic and Sergio Busquets.
Arturo Vidal and Carles Alena will come into contention for this one and could add some fresh legs in midfield.
It’s unlikely that Valverde will leave out both Rakitic and Busquets, but he could rest one of the duo with one eye on Wednesday’s trip to the Santiago Bernabeu.
Barcelona have been wasteful in attack in their last two outings and Valverde has decisions to make up front.
Luis Suarez has hit a poor patch of form, while Lionel Messi’s recent performances have attracted concern he’s not 100 per cent fit after a knock.
Ousmane Dembele should start again as he continues his recovery from injury, and Philippe Coutinho may also return to the starting XI after dropping to the bench against Lyon.
Malcom and Kevin-Prince Boateng are also options in attack if Valverde wants a completely fresh approach for his misfiring forward line.
Possible XI: Ter Stegen; Roberto, Pique, Lenglet, Alba; Vidal, Busquets, Alena; Dembele, Messi, Coutinho.
How do you think Barcelona should line up against Sevilla? Let us know your thoughts in the comments below!