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Barcelona are back at the Santiago Bernabeu on Saturday just days after enjoying a 3-0 win that sent them into the Copa del Rey final.
This time it’s La Liga points up for grabs with Barca going into the match already nine clear of Los Blancos.
There’s likely to be rotation from both teams for this one, so let’s have a look at who might feature.
Defence
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Marc-Andre ter Stegen was once again one of the stars of the show on Wednesday night, and he will continue in goal for the visitors.
The most likely change to the backline is Samuel Umtiti coming back in for Clement Lenglet.
The French defender made his long-awaited return from injury against Sevilla last weekend but sat out of the midweek fixture at the Bernabeu.
Midfield
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Barcelona will be hoping to welcome Arthur back from a calf injury against Real Madrid.
The Brazilian was a late sub in midweek after a calf injury but has not started since the 1-1 draw with Madrid at the start of February.
Also hoping for a starting spot will be Arturo Vidal and Carles Alena, although they may have to settle for a place on the bench again.
Attack
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Luis Suarez was back to his best against Real Madrid on Wednesday, and his record against Los Blancos (11 goals in 13 Clasicos) suggests it will be difficult to leave him out.
Lionel Messi and Ousmane Dembele may also continue in attack, although Ernesto Valverde does have options if he wants to freshen things up.
Philippe Coutinho and Malcom could come into the side, while Kevin-Prince Boateng may just be happy to make the squad after missing out entirely recently.
Possible XI: Ter Stegen; Semedo, Pique, Umtiti, Alba; Rakitic, Busquets, Arthur; Messi, Suarez, Dembele.
How do you think Barcelona should line up against Real Madrid? Let us know your thoughts in the comments below!