Setien’s men ran out 4-3 winners in La Liga at the Camp Nou in October and face Barcelona at the Benito Villamarín Stadium again on Sunday.
“We are convinced that we can put on a good performance and really compromise their playing style,” he said.
“And we are absolutely sure that we can give another important surprise in this match.”
Barcelona are on a fine run of form and have gone 12 matches without defeat in all competitions.
The team come into the match off a midweek Champions League victory over Lyon which hopefully will not have taken too much out of the team.