Celta lie just two points off the drop zone with three games left to play and are on a decent run of form with just one defeat in their last seven outings.
Ernesto Valverde is bound to rotate with the game coming in between two Champions League semi-finals against Liverpool, so let’s have a look at who might feature.
Expect wholesale changes at the back as Valverde gives his regulars a well-deserved rest. The only player likely to keep his place is Marc-Andre ter Stegen in goal, unless Jasper Cillessen is given a rare La Liga run-out.
Moussa Wague, Jean-Clair Todibo and Jeison Murillo all featured recently in the 0-0 draw at Huesca and will be hoping for more minutes. This game also represents another chance for Samuel Umtiti to remind everyone of his quality after a long injury lay-off.
Carles Alena should start this one in midfield, and fans will be hoping for another outing for Riqui Puig. The starlet has trained with the first team this week and looks set to feature.
Arturo Vidal could continue in midfield after another fine display in midweek, although Arthur would be the fresher option. Ivan Rakitic and Sergio Busquets are both suspended for yellow card accumulation.
Malcom has really struggled for game time recently, but this looks a perfect opportunity for the Brazilian to offer a reminder of his talents.
Ousmane Dembele could also come in from the start, and he’ll be hoping to impress and push for a place in the XI against Liverpool on Tuesday.
Kevin-Prince Boateng may make just his third La Liga appearance for Barcelona as Luis Suarez is overdue a rest and surely won’t feature. Lionel Messi should also get some rest, although don’t be surprised if he gets some minutes at some point.
Possible XI: Ter Stegen; Wague, Murillo, Todibo Umtiti; Arthur, Alena, Puig; Malcom, Boateng, Dembele.
How do you think Barcelona should line up against Celta? Let us know your thoughts, predictions and line-ups in the comments below!