Ronald Koeman is reportedly ready to rotate his team for the first time since taking over as Barcelona boss.
The Dutch coach has kept the same team for his first three fixtures, aside from bringing in Ronald Araujo for the suspended Clement Lenglet against Sevilla.
Yet Koeman is now pondering changes against Getafe on Saturday because the majority of his squad have been away on international duty and Barca have a busy end to the month.
According to Sport, new signings Miralem Pjanic, Francisco Trincao and Sergino Dest could all make their first La Liga starts for Barcelona.
Dest looks set to come into the team at at left-back at the Coliseum Alfonso Pérez as Jordi Alba and Junior Firpo remain on the injured list.
Pjanic could start in midfield and partner either Frenkie de Jong or Sergio Busquets. De Jong is actually in action tonight for the Netherlands against Italy.
In attack it seems that Philippe Coutinho or even Lionel Messi could get a rest having been back in South America over the international break for World Cup qualifiers.
If either player does drop out then Trincao appears to be the favorite to get the nod in attack and the chance to impress Koeman.
Barca are at Getafe on Saturday and then face Ferencvaros in the Champions League at the Camp Nou on Tuesday. Real Madrid follow four days later before Barca head to Juve.