The centre-back looked in real pain as he hobbled off in stoppage time and was replaced by Clement Lenglet for the final couple of minutes.
Quique Setien is short on defensive options, with Jean-Clair Todibo having left in January for Schalke, and will not want to be without Pique for Sunday’s trip to the Santiago Bernabeu.
Even Marca are reporting that Pique’s injury “isn’t serious” and point to the fact that Barca haven’t issued a medical statement as evidence, although they also reckon he will be monitored over the next few days.
Setien does have options if Pique doesn’t make it. Samuel Umtiti and Clement Lenglet are the most likely partnership, although Ronald Araujo is a right-sided centre-back who could come into the team.
However, the early signs suggest Pique will be fit to play on Sunday where a win would move Barca five points clear at the top of the table.