Quique Setien’s side have been superb at home this season and can’t afford to drop many more points if they are to retain their title.
Let’s have a look at who might feature:
Barcelona’s injuries in defence have cleared up which means Quique Setien doesn’t have too many decisions to make regarding his backline.
Marc-Andre ter Stegen will continue in goal and it seems likely Nelson Semedo and Jordi Alba will feature as the two full-backs.
Meanwhile, it’s a toss up between Clement Lenglet and Samuel Umtiti as Gerard Pique’s partner in central defence.
Barca’s midfield were overrun in the second half against Real Madrid which means Quique Setien may be tempted to make changes.
The Barca boss also needs to find a way to get the best out of Frenkie de Jong. The Dutchman played wide on the left last time out and looked pretty lost.
Arturo Vidal is another player who has featured in a variety of positions this season but could get the nod again on Saturday.
Setien has decisions to make in attack and must decide whether it’s time to hand Ansu Fati or Martin Braithwaite some game time against La Real.
Lionel Messi and Antoine Griezmann look certain to start again but haven’t been anywhere near their best recently and the attack needs livening up.
Possible XI: Ter Stegen; Semedo, Pique, Lenglet, Alba; Arthur, Busquets, De Jong; Messi, Griezmann, Braithwaite.
How do you think Barcelona will line up on Saturday? Let us know your thoughts, predictions and line-ups in the comments below!