Let’s look at how they might line-up:
Junior Firpo has trained this week after a hip injury and could be handed a rare start at left-back to give Jordi Alba a breather.
In central defence Samuel Umtiti remains on the injured list, but Ronald Araujo is available if Setien does want to freshen things up.
The 21-year-old was a late substitute against Espanyol and could be used if Gerard Pique, who’s played virtually every minute since the restart, needs a rest.
Setien has few injury problems in midfield and plenty of options so it will be interesting to see which players he selects for Saturday’s match.
Frenkie de Jong has returned to training this week after a calf problem and could be ready to make just his second appearance since the restart.
Riqui Puig is also pushing hard for a place after dropping out of the starting XI for Barca’s last two outings.
Ansu Fati will have to sit this one out after his red card against Espanyol which means it’s likely Antoine Griezmann, Lionel Messi and Luis Suarez will continue in attack.
Setien could look to bring in Martin Braithwaite to freshen things up. The Dane hasn’t seen too much time game recently and hasn’t started since the 0-0 draw with Sevilla.
Possible XI: Ter Stegen; Semedo, Araujo, Lenglet, Junior; De Jong, Busquets, Puig; Messi, Suarez, Griezmann.
How do you think Barcelona will line up on Saturday? Let us know your thoughts, predictions and line-ups in the comments below!