Ernesto Valverde’s men are on a three-match winless run but won their first group game 4-0 against PSV Eindhoven.
There have been some murmurings that Barcelona could switch back to 4-4-2 for this game. Let’s have a look at who may feature.
Samuel Umtiti is suspended and Sergi Roberto has been ruled out through injury which makes the defensive line-up pretty straightforward.
The only debate really concerns whether it will be Clement Lenglet or Thomas Vermaelen who partners Gerard Pique in central defence. The Frenchman is expected to play.
Pique has not been in great form recently, but he’ll be making his 100th Champions League appearance if he features against Tottenham.
Otherwise, it’ll be Nelson Semedo and Jordi Alba as the two full-backs, with Marc-Andre ter Stegen in goal.
This is where it gets interesting. Will Valverde change formation in a bid to try and get an improved performance out of his team?
What we probably do know is that Ivan Rakitic, Sergio Busquets and Philippe Coutinho will all start which just leaves one spot up for grabs in either midfield or further forward depending on which formation he goes with.
Ousmane Dembele has been a regular so far this season but has gone off the boil a little, Arturo Vidal played well against Athletic at the weekend, while Arthur is also a possible option. Malcom’s not in the squad and it would be a surprise if either Denis Suarez or Rafinha were to start.
Lionel Messi will return to the starting XI after starting on the bench against Athletic, and he’ll join Luis Suarez in attack.
Messi has 20 goals in 28 games against English sides but has gone two games without finding the back of the net for Barcelona.
Suarez has found goals difficult to come by in the Champions League in recent seasons. He seemed to enjoy playing Spurs as a Liverpool player though, scoring four goals in seven appearances.
Possible starting XI: Ter Stegen; Semedo, Pique, Lenglet, Alba; Rakitic, Busquets, Vidal, Coutinho; Messi, Suarez.
How do you think Barcelona should line up against Tottenham? Let us know your thoughts, team selections and predictions in the comments below!