It’s a big game for Spurs who need to win to go through, while Barcelona have already sealed top spot and have nothing to play for.
Ernesto Valverde will be expected to rotate, but it’s difficult to say just how many changes he will make. Let’s have a look at who could feature.
In goal there’s a chance Jasper Cillessen could get a rare run-out in order to give Marc-Andre ter Stegen a rest.
Injuries at the back mean Barcelona are still without Sergi Roberto and Samuel Umtiti, Thomas Vermaelen could come in and youngsters Chumi and Juan Miranda will be hoping for another run-out after appearing in the Copa del Rey last week.
This looks an ideal game to finally give Ivan Rakitic a rest, and Valverde has plenty of options to play in midfield.
Arturo Vidal has shone for Barcelona in recent weeks, Arthur is expected to be fit after injury and Denis Suarez plus youngsters Carles Alena, Oriol Busquets and even Riqui Puig will be hoping for some minutes.
Expect changes in attack too with Luis Suarez the big-name most likely to miss out due to ongoing concerns over his knee injury.
Munir could make a rare start, Philippe Coutinho could return to the starting XI after injury and might we see Lionel Messi too?
Possible starting XI: Cillessen; Semedo, Chumi, Vermaelen, Miranda; Vidal, Busquets, Arthur; Messi, Munir, Coutinho
How do you think Barcelona should line up against Tottenham? Let us know your thoughts, predictions and line-ups in the comments below!