The two teams have plenty of history in the competition and there have been a few controversial matches between the clubs.
The first leg takes place at Stamford Bridge on Tuesday and Azpilicueta has warnd that Barcelona legend Andres Iniesta may not get a warm welcome.
The midfielder scored the goal that knocked Chelsea out of the competition in the semi-finals in 2009, and home fans will not have forgotten that moment, says Azpilicueta.
“I remember that I was in Osasuna when he scored that goal to take Barcelona to the final in Rome,” he said.
”That changed his history so much and I think the Chelsea fans still feel that in their hearts.
”I think Andres continues to generate nightmares and I do not think he will get a good reception.”
Source | AS
Tuesday’s game promises to be a fascinating match-up, with Barcelona on a great run but not entirely convincing recently. Chelsea, meanwhile, have had an inconsistent season and are difficult to predict.