Ernesto Valverde’s side hold a healthy 4-1 lead from the first leg and will be favourites to progress but how will they line up?
Nelson Semedo has been playing well since returning to the first team and could keep his place at right-back with Sergi Roberto again moving into midfield.
Samuel Umtiti should return in central defence alongside Gerard Pique with Jordi Alba back at left-back and Marc-Andre ter Stegen in goal.
The big question in midfield is whether Sergio Busquets will be fit enough to play, and if not who will take his place?
Busquets missed the win over Leganes but is in the squad for the trip to Roma, but it remains to be seen if he’s fit enough to start the game.
If not Valverde does have options, not least Andre Gomes who came in at the weekend and put in a decent display. Paulinho is also in contention for a start.
Elsewhere, Ivan Rakitic should start again with Andres Iniesta coming in for the ineligible Philippe Coutinho. That just leaves the right side and it’s possible we could see Roberto in midfield again in place of Ousmane Dembele.
In attack Lionel Messi comes into the game fresh from a hat-trick but Valverde has shown this season he’s not afraid to rest his star man in the Champions League.
Paco Alcacer is an option if Messi is given a break alongside Luis Suarez.
Possible starting XI: Ter Stegen; Semedo, Pique, Umtiti, Alba; Roberto, Rakitic, Busquets, Iniesta; Messi, Suarez.
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